Staph Lab

Research

Overview

Our research interests have focused on the Staphylococci, a broad genus of Gram-positive cocci that includes the well known pathogen Staphylococcus aureus and commensal bacteria often referred to as coagulase-negative Staphylococci.  S. aureus is one of the most frequent causes of bacterial infections in healthcare and community settings, and in particular it is the dominant cause of skin infections.  At the same time, approximately 20-30% of the healthy adult population is colonized with S. aureus asymptomatically in the anterior nares of the nose and secondarily on the skin. Antibiotic resistance levels, such as methicillin-resistant S. aureus (MRSA), have continued to rise and become epidemic in many healthcare settings, limiting available treatment options and leading to worse patient outcomes.

Within the area of S. aureus research, our group has focused on variety of topics that includes cell-to-cell communication (quorum sensing), biofilm development, host pathogen interactions, and therapeutic development.  More recently, we’ve initiated projects on polymicrobial interactions and Gram negative pathogens.  Visit the following pages to learn more about our research.

© 2017, All Rights Reserved.
Horswill Laboratory, University of Colorado.

Designed by

Lab Info
Research Complex 1 North
12800 E. 19th Ave., Rm. P18-9101

Alexandar Horswill, PhD
Professor of Immunology and Microbiology

(303) 724-3534
alexander.horswill@ucdenver.edu